Influence of the pH on the itaconic acid production with Aspergillus terreus
作者： Antje Hevekerl , Anja Kuenz , Klaus-Dieter Vorlop
DOI: 10.1007/S00253-014-6047-2
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摘要: Itaconic acid is mainly produced with the filamentous fungi Aspergillus terreus. An increase in pH during production phase of cultivation resulted an itaconic concentration. The was raised by a single shift ranging from 4 to 6 or control 3. Different lyes can be used for shift, but ammonia solution has proven best, because here productivity does not drop after shift. highest concentration 146 g/L reached when 3 started 2.1 days cultivation. This 68 % without control. When this technique combined previously found optimizations, final 129 4.7 cultivation, resulting 1.15 g/L/h.
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H. Larsen, K. E. Eimhjellen, The mechanism of itaconic acid formation by Aspergillus terreus. 1. The effect of acidity Biochemical Journal. ,vol. 60, pp. 135- 139 ,(1955) , 10.1042/BJ0600135
Carlos R. Soccol, Cristine Rodrigues, Ashok Pandey, Luciana P. S. Vandenberghe, New perspectives for citric acid production and application Food Technology and Biotechnology. ,vol. 44, pp. 141- 149 ,(2006)
Th. Willke, K.-D. Vorlop, Biotechnological production of itaconic acid Applied Microbiology and Biotechnology. ,vol. 56, pp. 289- 295 ,(2001) , 10.1007/S002530100685
Emanuele Riscaldati, Mauro Moresi, Maurizio Petruccioli, Federico Federici, Effect of pH and stirring rate on itaconate production by Aspergillus terreus. Journal of Biotechnology. ,vol. 83, pp. 219- 230 ,(2000) , 10.1016/S0168-1656(00)00322-9
Kazutoyo Yahiro, Tetsushi Takahama, Young Soo Park, Mitsuyasu Okabe, Breeding of Aspergillus terreus mutant TN-484 for itaconic acid production with high yield Journal of Fermentation and Bioengineering. ,vol. 79, pp. 506- 508 ,(1995) , 10.1016/0922-338X(95)91272-7
Mark X. Caddick, Alan G. Brownlee, Herbert N. Arst, Regulation of gene expression by pH of the growth medium in Aspergillus nidulans. Molecular Genetics and Genomics. ,vol. 203, pp. 346- 353 ,(1986) , 10.1007/BF00333978
M. H. Gyamerah, Oxygen requirement and energy relations of itaconic acid fermentation by Aspergillus terreus NRRL 1960 Applied Microbiology and Biotechnology. ,vol. 44, pp. 20- 26 ,(1995) , 10.1007/BF00164475
Antje Hevekerl, Anja Kuenz, Klaus-Dieter Vorlop, Filamentous fungi in microtiter plates—an easy way to optimize itaconic acid production with Aspergillus terreus Applied Microbiology and Biotechnology. ,vol. 98, pp. 6983- 6989 ,(2014) , 10.1007/S00253-014-5743-2
Mojmir Rychtera, D. A. John Wase, The growth of Aspergillus terreus and the production of itaconic acid in batch and continuous cultures. The influence of pH Journal of Chemical Technology and Biotechnology. ,vol. 31, pp. 509- 521 ,(2007) , 10.1002/JCTB.503310168
Yong Soo Park, Noriyasu Ohta, Mitsuyasu Okabe, Effect of dissolved oxygen concentration and impeller tip speed on itaconic acid production by Aspergillus terreus Biotechnology Letters. ,vol. 15, pp. 583- 586 ,(1993) , 10.1007/BF00138544