A human astrocytoma cell line is highly susceptible to infection with Trypanosoma cruzi

摘要: Astrocytes play a vital role in neuronal protection, homeostasis, vascular interchange and the local immune response. Some viruses parasites can cross blood-brain barrier infect glia. Trypanosoma cruzi, aetiological agent of Chagas disease, seriously compromise central nervous system, mainly immune-suppressed individuals, but also during acute phase infection. In this report, infective capacity T. cruzi human astrocyte tumour-derived cell line was studied. exposed to trypomastigotes (1:10 ratio) produced intracellular amastigotes new emerged by day 4 post-infection (p.i.). At 6 p.i., 93% cells were infected. Using flow cytometry, changes observed both expression major histocompatibility complex class I II molecules chemokine secretion pattern astrocytes parasite. Blocking low-density lipoprotein receptor on did not reduce parasite Thus, modulate response system