EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer

摘要: Recent experiments have demonstrated that the Polycomb group (PcG) gene EZH2 is highly expressed in metastatic prostate cancer and lymphomas. a component of PRC2 histone methyltransferase complex, which also contains EED SUZ12 required for silencing HOX expression during embryonic development. Here we demonstrate both are essential proliferation transformed non-transformed human cells. In addition, pRB-E2F pathway tightly regulates their and, consistent with this, find large set tumors. These results raise question whether marker or if it actually contributing to tumor formation. Significantly, propose bona fide oncogene, since ectopic capable providing proliferative advantage primary cells its locus specifically amplified several