Porphyrins as Photosensitizers

摘要: The porphyrins have two important roles in photobiology: photosynthesis, which has evolved and is highly organized morphologically; the photodynamic effect, adventitious. damage to tissue that results from action regarded as arising a number of pathways, but singlet oxygen generation major route. Even for latter mechanism, target molecules are possible. Compared with it very disorganized process. Since mid 1970s there been increasing efforts turn effect good use basis phototherapy cancer. field dominated by photosensitizer haematoporphyrin derivative. This complex mixture molecules, although we learning more about it, seems unlikely will be possible separate out useful single substance. A second porphyrin sensitizers emerging, which, unlike derivative, designed job hand. Some these photosensitizers, especially hydroporphyrins, look quite promising.