Monocyte interleukin 2 receptor gene expression and interleukin 2 augmentation of microbicidal activity.

摘要: Activation of human peripheral blood monocytes results in the expression interleukin 2 (IL 2) receptors, which are absent on resting monocytes. In a population purified monocytes, appearance IL receptors occurs majority cells association with increased levels HLA-DR. Lipopolysaccharide (LPS) induces maximum numbers within 12 hr, whereas IFN-gamma requires 48 hr. We used cDNA encoding for receptor to evaluate gene and activated Within 4 hr after LPS stimulation, mRNA species 3500 1500 bases appear, reaching peak between 8 declining thereafter. The LPS-activated monocyte protein is expressed cell surface few hours detection mRNA. addition receptor-positive augments their generation reactive oxygen intermediates cytotoxic activity. Thus when undergo series morphologic, phenotypic, functional changes, including may provide an important immunoregulatory pathway.