Are the effects of tamoxifen on the serum lipid profile modified by apolipoprotein E phenotypes

摘要: Background: Tamoxifen has favorable effects on the serum lipid profile. It been suggested that apolipoprotein (Apo) E phenotype can influence parameters; ApoE allele 4 (ApoE4) is associated with higher total and low-density lipoprotein (LDL) cholesterol levels. The also affects responses to diets or treatment statins. However, effect of tamoxifen profile in different phenotypes unknown. Patients Methods: In present study, we evaluated 11 ApoE4-positive postmenopausal women breast cancer (phenotypes 3/4 4/4) compared 33 ApoE4-negative 3/2 3/3). Serum parameters [high-density (HDL), LDL cholesterol, triglycerides, ApoAI, ApoB (a)] were measured after an overnight fast before 3 12 months. isoforms determined by isoelectric focusing delipidated very-low-density lipoproteins (VLDL). Results: During follow-up period, levels decreased significantly both groups, but no significant differences found. Concentrations HDL not between groups. ApoAI increased subjects (p = 0.00005), changes observed. triglyceride 23.2% Conclusion: Greek cancer, Lp(a) triglycerides ApoAI/ApoB ratio respond more favorably than patients.