Breast Cancer Subtypes and the Risk of Local and Regional Relapse
作者： K. David Voduc , Maggie C.U. Cheang , Scott Tyldesley , Karen Gelmon , Torsten O. Nielsen
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摘要: Purpose The risk of local and regional relapse associated with each breast cancer molecular subtype was determined in a large cohort patients cancer. Subtype assignment accomplished using validated six-marker immunohistochemical panel applied to tissue microarrays. Patients Methods Semiquantitative analysis estrogen receptor (ER), progesterone (PR), Ki-67, human epidermal growth factor 2 (HER2), (EGFR), cytokeratin (CK) 5/6 performed on microarrays constructed from 2,985 early invasive were classified into the following categories: luminal A, B, luminal-HER2, HER2 enriched, basal-like, or triple-negative phenotype‐nonbasal. Multivariable Cox used determine intrinsic subtypes, adjusting for standard clinicopathologic factors. Results successfully tumors. median follow-up time 12 years, there have been total 325 recurrences 227 lymph node recurrences. Luminal A tumors (ER PR positive, negative, Ki-67 14%) had best prognosis lowest rate relapse. For undergoing conservation, HER2-enriched basal subtypes demonstrated an increased recurrence, this statistically significant multivariable analysis. After mastectomy, HER2-enriched, all
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