Efficient and simple zinc-mediated synthesis of 3-amidoindoles.
作者： Anahit Pews-Davtyan , Matthias Beller
DOI: 10.1039/C1OB05576C
关键词:
摘要: A general synthesis of 3-amidoindoles from easily available arylhydrazines and acylated propargylamines is described. In the presence inexpensive Zn salts, alkyne amination subsequent Fischer indole-cyclization took place in good yields with excellent regioselectivity providing an interesting scaffold for potentially bio-active compounds.
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