5-Hydroxyindole-type alkaloids, as Candida albicans isocitrate lyase inhibitors, from the tropical sponge Hyrtios sp.
作者： Hyi-Seung Lee , Kyung-Mi Yoon , Yu-Ri Han , Kyung Jin Lee , Soon-Chun Chung
DOI: 10.1016/J.BMCL.2009.01.017
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摘要: Chemical investigations of the tropical marine sponge Hyrtios sp. have resulted in isolation a new alkaloid, 1-carboxy-6-hydroxy-3,4-dihydro-beta-carboline (1) together with known metabolites, 6-hydroxy-3,4-dihydro-1-oxo-beta-carboline (2), 5-hydroxy-1H-indole-3-carboxylic acid methyl ester (3), serotonin (4), hyrtiosin A (5), 5-hydroxyindole-3-carbaldehyde (6), and B (7). Their structures were elucidated on basis mass spectrometry detailed 2D NMR spectroscopic data. Hyrtiosin (7) displayed potent inhibitory activity against isocitrate lyase (ICL) Candida albicans an IC(50) value 89.0 microM.
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