Initial accumulation of paraquat in the heart leading to acute death.

摘要: Abstract When a large amount of paraquat (364 mg/kg) which caused death in several hours was orally ingested rats, the herbicide concentration blood continued to increase until animal died. Furthermore, there correlation between blood, heart, liver and adrenal gland survival time. While heart had most evident those tissues (r = -0.962), no time lung or kidney. ECG rats died early stages showed severe damage heart. It found by histopathological studies that edema, congestion hemorrhage occurred myocardium shortly after administration mg/kg). These results suggest rapid accumulation into may play an important role cause acute death.