Paraquat intoxication induced sick sinus syndrome

摘要: Abstract Introduction: Paraquat (1,1’-dimethyl-4, 4’-dipyridylium) intoxication is a major medical problem in developing countries. The ingestion of paraquat fatal humans and its mortality rate as high 50%. has systemic effect on the lung, kidney, gastrointestinal tract, central nervous system, even heart. Case report: A female patient visited our emergency room after suicidal herbicide. received conventional treatment, including gastric lavage with large amounts normal saline charcoal, steroids antioxidant therapy. Hemoperfusion was consecutively done twice within 12 hours. During her heart abruptly dropped to below 50 beats per minute she complained associated symptoms like dizziness weakness. At that time systolic blood pressure 80 mmHg. sinus bradycardia shown electrocardiogram (ECG) 24 hours ambulatory ECG monitoring showed severe bradycardia, sometimes junctional escape rhythms, non-conducted atrial premature complexes. We administered dopamine an inotropic agent for two days. After prompt rhythm returned back stabilized. Discussion: one most severely affected organs intoxication. intoxication, cardiac complications arrhythmia or myocardial necrosis aggravate general condition patients. Consequently, early detection multi-organ dysfunctions initiation proper management specific organ injuries are very important prognosis intoxicated paraquat, especially case involvement such arrhythmia, others.