Requirement for Brn-3.0 in differentiation and survival of sensory and motor neurons.
作者： Robert J. McEvilly , Linda Erkman , Lin Luo , Paul E. Sawchenko , Allen F. Ryan
DOI: 10.1038/384574A0
关键词:
摘要: SPECIFIC families of transcription factors mediate events in the sequential maturation distinct neuronal phenotypes. Members one such family, class IV POU domain factor Brn-3.0, and two highly related Brn-3.1 Brn-3.2, are differentially expressed developing mature mamma-lian nervous system1–11. The expression pattern Brn-3.0 sug-gested that it has an important role development sensory ganglia, as well red nucleus, inferior olive, nucleus ambiguus. Analysis mice null for locus shows is required survival subpopulations proprioceptive, mechanoreceptive nociceptive neu-rons, where deletion gene affects neurotrophin neuro-trophin-receptor expression. Deletion also alters either differentiation, migration or specific central populations.
harvard.edu
nature.com
sci-hub.se 参考文章(28)
ET Cunningham, PE Sawchenko, A circumscribed projection from the nucleus of the solitary tract to the nucleus ambiguus in the rat: anatomical evidence for somatostatin- 28-immunoreactive interneurons subserving reflex control of esophageal motility The Journal of Neuroscience. ,vol. 9, pp. 1668- 1682 ,(1989) , 10.1523/JNEUROSCI.09-05-01668.1989
Robert G. Collum, Peter E. Fisher, Milton Datta, Scott Mellis, Carol Thiele, Kay Huebner, Carlo M. Croce, Mark A. Israel, Thomas Theil, Tarik Morory, Ronald DePinho, Frederick W. Alt, A novel POU homeodomain gene specifically expressed in cells of the developing mammalian nervous system. Nucleic Acids Research. ,vol. 20, pp. 4919- 4925 ,(1992) , 10.1093/NAR/20.18.4919
Michael Finney, Gary Ruvkun, H.Robert Horvitz, The C. elegans cell lineage and differentiation gene unc-86 encodes a protein with a homeodomain and extended similarity to transcription factors Cell. ,vol. 55, pp. 757- 769 ,(1988) , 10.1016/0092-8674(88)90132-8
Suzanne L. Mansour, Kirk R. Thomas, Mario R. Capecchi, Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes Nature. ,vol. 336, pp. 348- 352 ,(1988) , 10.1038/336348A0
Linda Erkman, Robert J. McEvilly, Lin Luo, Aimee K. Ryan, Farideh Hooshmand, Shawn M. O'Connell, Elizabeth M. Keithley, David H. Rapaport, Alien F. Ryan, Michael G. Rosenfeld, Role of transcription factors Brn-3.1 and Brn-3.2 in auditory and visual system development. Nature. ,vol. 381, pp. 603- 606 ,(1996) , 10.1038/381603A0
L. Gan, M. Xiang, L. Zhou, D. S. Wagner, W. H. Klein, J. Nathans, POU domain factor Brn-3b is required for the development of a large set of retinal ganglion cells Proceedings of the National Academy of Sciences of the United States of America. ,vol. 93, pp. 3920- 3925 ,(1996) , 10.1073/PNAS.93.9.3920
Eric E. Turner, Keith J. Jenne, Michael G. Rosenfeld, Brn-3.2: a Brn-3-related transcription factor with distinctive central nervous system expression and regulation by retinoic acid. Neuron. ,vol. 12, pp. 205- 218 ,(1994) , 10.1016/0896-6273(94)90164-3
Olof Karlsson, Stefan Thor, Torbjörn Norberg, Helena Ohlsson, Thomas Edlund, Insulin gene enhancer binding protein Isl-1 is a member of a novel class of proteins containing both a homeo-and a Cys–His domain Nature. ,vol. 344, pp. 879- 882 ,(1990) , 10.1038/344879A0
I. R. Schwartz, A. F. Ryan, Autoradiographic studies of selective amino acid uptake by neural and nonneural elements in the gerbil cochlea Journal of Electron Microscopy Technique. ,vol. 15, pp. 225- 244 ,(1990) , 10.1002/JEMT.1060150304
J. C. Conover, J. T. Erickson, D. M. Katz, L. M. Bianchi, W. T. Poueymirou, J. McClain, L. Pan, M. Helgren, N. Y. Ip, P. Boland, B. Friedman, S. Wiegand, R. Vejsada, A. C. Kato, T. M. DeChiara, G. D. Yancopoulos, Neuronal deficits, not involving motor neurons, in mice lacking BDNF and/or NT4. Nature. ,vol. 375, pp. 235- 238 ,(1995) , 10.1038/375235A0