The potential role of hypocortisolism in the pathophysiology of PTSD and psoriasis.

摘要: Different physical, chemical and psychological stressors can provoke a unique but different endocrine response involving activation of the hypothalamo-pituitary-adrenal (HPA) axis. Inability adequate compensatory reaction lead to many disorders. The aim our study was comparison cortisol values in diseases provoked by various stressors. Our investigation included 34 posttraumatic stress disorder (PTSD) patients, as an example caused extremely strong, acute stressful stimulus, 19 psoriatic chronic stimulus 17 healthy volunteers. In each patient we determined 24-hour urinary cortisol, serum at 8 a.m. 5 p.m., dexamethasone suppression test standard radioimmunoassay (RIA) method. PTSD patients showed lower values, (361 +/- 28 nmol/24 h), "stronger" circadian rhythm (595 57 nmol/l 242 23 p.m.) attenuated (197 45 nmol/l) volunteers (590 87 h urine, 590 32 a.m., 402 31 nmol/l, < 86 dexa test). Psoriatic markedly (150 98 even then (404 138 187 80 enhanced (23 nmol/l). model feedback inhibition shows that they are unusually reactive represents alternative strong stimulus. Unusually low correlate hypothesis stress-related disease, psoriasis is, exists, still undefined mechanism, altered HPA axis function, which is obviously incompetent realise its immunoregulatory so consequentially, clinical signs persist.