Protection of White Leghorn chickens by U.S. emergency H5 vaccination against clade 2.3.4.4 H5N2 high pathogenicity avian influenza virus.
作者： Kateri Bertran , Charles Balzli , Dong-Hun Lee , David L. Suarez , Darrell R. Kapczynski
DOI: 10.1016/J.VACCINE.2017.05.051
关键词:
摘要: During December 2014-June 2015, the U.S. experienced a high pathogenicity avian influenza (HPAI) outbreak caused by clade 2.3.4.4 H5Nx Goose/Guangdong lineage viruses with devastating consequences for poultry industry. Three vaccines, developed based on updating existing registered vaccines or currently licensed technologies, were evaluated possible use: an inactivated reverse genetics H5N1 vaccine (rgH5N1) and RNA particle (RP-H5), both containing hemagglutinin gene of strain, recombinant herpesvirus turkey vectored (rHVT-H5) 2.2 strain. The efficacy three alone in combination, was assessed White Leghorn chickens against H5N2 HPAI virus challenge. In Study 1, single prime-boost (rHVT-H5+rgH5N1 rHVT-H5+RP-H5) vaccination strategies protected levels protective immunity significantly reduced shedding. 2, either rgH5N1 RP-H5 provided clinical protection adult 3, double from signs mortality when challenged 20weeks post-boost, long-lasting These studies support use genetically related possibly combination broad priming vaccine, emergency programs young layer chickens.
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