Demystifying FluMist, a new intranasal, live influenza vaccine.

作者: S. B Mossad

DOI: 10.3949/CCJM.70.9.801

关键词:

摘要: FluMist—a cold-adapted, live-attenuated, trivalent, intranasal influenza virus vaccine approved by the US Food and Drug Administration on June 17, 2003—has been shown to be safe effective, but its role in general prevention of is yet defined. Intranasal administration expected more acceptable than parenteral, particularly children, potential for shedding live may pose a risk anyone with compromised immune system.

参考文章(21)
Scott A Harper, Keiji Fukuda, Timothy M Uyeki, Nancy J Cox, Carolyn B Bridges, None, Prevention and control of influenza : recommendations of the Advisory Committee on Immunization Practices (ACIP) Morbidity and Mortality Weekly Report. ,vol. 55, pp. 1- 40 ,(2004)
M.D Wareing, G.A Tannock, Live attenuated vaccines against influenza; an historical review Vaccine. ,vol. 19, pp. 3320- 3330 ,(2001) , 10.1016/S0264-410X(01)00045-7
H. F. MAASSAB, Adaptation and Growth Characteristics of Influenza Virus at 25° C Nature. ,vol. 213, pp. 612- 614 ,(1967) , 10.1038/213612A0
William C. Gruber, Paul M. Darden, J. Gordon Still, Jacob Lohr, George Reed, Peter F. Wright, Evaluation of bivalent live attenuated influenza A vaccines in children 2 months to 3 years of age: safety, immunogenicity and dose-response Vaccine. ,vol. 15, pp. 1379- 1384 ,(1997) , 10.1016/S0264-410X(97)00032-7
Thomas G. Boyce, William C. Gruber, Shanita D. Coleman-Dockery, Edith C. Sannella, George W. Reed, Mark Wolff, Peter F. Wright, Mucosal immune response to trivalent live attenuated intranasal influenza vaccine in children. Vaccine. ,vol. 18, pp. 82- 88 ,(1999) , 10.1016/S0264-410X(99)00183-8
Ira M Longini, M.Elizabeth Halloran, Azhar Nizam, Mark Wolff, Paul M Mendelman, Patricia E Fast, Robert B Belshe, Estimation of the efficacy of live, attenuated influenza vaccine from a two-year, multi-center vaccine trial: implications for influenza epidemic control. Vaccine. ,vol. 18, pp. 1902- 1909 ,(2000) , 10.1016/S0264-410X(99)00419-3