Antisense transcript long noncoding RNA (lncRNA) HOTAIR is transcriptionally induced by estradiol
作者： Arunoday Bhan , Imran Hussain , Khairul I. Ansari , Sahba Kasiri , Aarti Bashyal
DOI: 10.1016/J.JMB.2013.01.022
关键词:
摘要: Abstract HOTAIR (HOX antisense intergenic RNA) is a long noncoding RNA (lncRNA) that is transcribed from the antisense strand of homeobox C gene locus in chromosome 12. HOTAIR coordinates with chromatin-modifying enzymes and regulates gene silencing. It is overexpressed in various carcinomas including breast cancer. Herein, we demonstrated that HOTAIR is crucial for cell growth and viability and its knockdown induced apoptosis in breast cancer cells. We also demonstrated that HOTAIR is transcriptionally induced by estradiol …
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