Growth Hormone (GH) Responsiveness to Combined Administration of Arginine and GH-Releasing Hormone Does not Vary with Age in Man*
作者： EZIO GHIGO , STEFANIA GOFFI , MARIO NICOLOSI , EMANUELA ARVAT , FRANCESCA VALENTE
关键词:
摘要: At present, the mechanism(s) underlying reduced spontaneous and stimulated GH secretion in aging is still unclear. To obtain new information on this mechanism(s), responses to both single combined administration of GH-releasing hormone (GHRH; 1 μg/kg iv) arginine (ARG; 30 g infused over min), a well known secretagogue probably acting via inhibition hypothalamic somatostatin release, were studied seven elderly normal subjects young healthy subjects. Basal levels similar groups, while insulinlike growth factor/I lower (76.7 ± 9.2 vs. 258.3 29.2 μg/L; P = 0.01). In aged GHRH induced increase (area under curve, 314.9 91.9 ng/L·h) which was (P 0.01) than that (709.1 114.4 Mg/Lh). On other hand, ARG-induced not significantly different from (372.8 81.8 470.6 126.5 μg/L·h). ARG potentiated responsiveness ...
oup.com
endojournals.org参考文章(41)
William B. Wehrenberg, Nicholas Ling, The absence of an age-related change in the pituitary response to growth hormone-releasing factor in rats. Neuroendocrinology. ,vol. 37, pp. 463- 466 ,(1983) , 10.1159/000123594
A. Torsello, G. Panzeri, P. Cermenati, M. C. Caroleo, E. Ghigo, F. Camanni, E. E. Müller, V. Locatelli, Involvement of the somatostatin and cholinergic systems in the mechanism of growth hormone autofeedback regulation in the rat. Journal of Endocrinology. ,vol. 117, pp. 273- 281 ,(1988) , 10.1677/JOE.0.1170273
V. De Gennaro Colonna, M. Zoli, D. Cocchi, A. Maggi, P. Marrama, L.F. Agnati, E.E. Müller, Reduced growth hormone releasing factor (GHRF)-like immunoreactivity and GHRF gene expression in the hypothalamus of aged rats. Peptides. ,vol. 10, pp. 705- 708 ,(1989) , 10.1016/0196-9781(89)90164-2
Irit Gil-Ad, Rachel Gurewitz, Ozias Marcovici, Joseph Rosenfeld, Zvi Laron, Effect of aging on human plasma growth hormone response to clonidine. Mechanisms of Ageing and Development. ,vol. 27, pp. 97- 100 ,(1984) , 10.1016/0047-6374(84)90086-1
K. Y. HO, W. S. EVANS, R. M. BLIZZARD, J. D. VELDHUIS, G. R. MERRIAM, E. SAMOJLIK, R. FURLANETTO, A. D ROGOL, D. L. KAISER, M. O. THORNER, Effects of sex and age on the 24-hour profile of growth hormone secretion in man: importance of endogenous estradiol concentrations The Journal of Clinical Endocrinology and Metabolism. ,vol. 64, pp. 51- 58 ,(1987) , 10.1210/JCEM-64-1-51
Ferdinando Massara, Ezio Ghigo, Konstantinos Demislis, Domenico Tangolo, Enrico Mazza, Vittorio Locatelli, Eugenio E. Müller, GianMichele Molinatti, Franco Camanni, Cholinergic involvement in the growth hormone releasing hormone-induced growth hormone release: studies in normal and acromegalic subjects. Neuroendocrinology. ,vol. 43, pp. 670- 675 ,(1986) , 10.1159/000124602
MARY L. PARKER, JAMES M. HAMMOND, WILLIAM H. DAUGHADAY, The arginine provocative test: an aid in the diagnosis of hyposomatotropism. The Journal of Clinical Endocrinology and Metabolism. ,vol. 27, pp. 1129- 1136 ,(1967) , 10.1210/JCEM-27-8-1129
Patrick Robberecht, Michel Gillard, Magali Waelbroeck, Jean-Claude Camus, Philippe De Neef, Jean Christophe, Decreased stimulation of adenylate cyclase by growth hormone-releasing factor in the anterior pituitary of old rats. Neuroendocrinology. ,vol. 44, pp. 429- 432 ,(1986) , 10.1159/000124682
JORDAN W. FINKELSTEIN, HOWARD P. ROFFWARG, ROBERT M. BOYAR, JACOB KREAM, LEON HELLMAN, Age-related change in the twenty-four-hour spontaneous secretion of growth hormone. The Journal of Clinical Endocrinology and Metabolism. ,vol. 35, pp. 665- 670 ,(1972) , 10.1210/JCEM-35-5-665
C. LYNNE BUREK, LAWRENCE A. FROHMAN, Growth hormone synthesis by rat pituitaries in vitro: effect of age and sex. Endocrinology. ,vol. 86, pp. 1361- 1367 ,(1970) , 10.1210/ENDO-86-6-1361