Computational Design of Helical Peptides Targeting TNFα
作者： Changsheng Zhang , Qi Shen , Bo Tang , Luhua Lai
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摘要: Find and bind: A computational strategy for designing single-helical peptides that can bind to a target protein was developed. After identification of potential helix-binding positions, sequences binding conformations were derived theoretically, explored by experimental screening. This method successfully applied in peptide inhibitors therapeutic target, tumor necrosis factor-α (TNFα).
sci-hub.se 参考文章(21)
Virginia Gewin, Turning point: Charalampos Kalodimos Nature. ,vol. 468, pp. 859- 859 ,(2010) , 10.1038/NJ7325-859A
H Loetscher, D Stueber, D Banner, F Mackay, W Lesslauer, Human tumor necrosis factor alpha (TNF alpha) mutants with exclusive specificity for the 55-kDa or 75-kDa TNF receptors. Journal of Biological Chemistry. ,vol. 268, pp. 26350- 26357 ,(1993) , 10.1016/S0021-9258(19)74322-1
X.M. Zhang, I Weber, M.J. Chen, Site-directed mutational analysis of human tumor necrosis factor-alpha receptor binding site and structure-functional relationship. Journal of Biological Chemistry. ,vol. 267, pp. 24069- 24075 ,(1992) , 10.1016/S0021-9258(18)35947-7
M.J. Eck, S.R. Sprang, The structure of tumor necrosis factor-alpha at 2.6 A resolution. Implications for receptor binding. Journal of Biological Chemistry. ,vol. 264, pp. 17595- 17605 ,(1990) , 10.2210/PDB1TNF/PDB
Changsheng Zhang, Luhua Lai, Towards structure-based protein drug design Biochemical Society Transactions. ,vol. 39, pp. 1382- 1386 ,(2011) , 10.1042/BST0391382
Brooke N. Bullock, Andrea L. Jochim, Paramjit S. Arora, Assessing helical protein interfaces for inhibitor design. Journal of the American Chemical Society. ,vol. 133, pp. 14220- 14223 ,(2011) , 10.1021/JA206074J
Deanne W. Sammond, Dustin E. Bosch, Glenn L. Butterfoss, Carrie Purbeck, Mischa Machius, David P. Siderovski, Brian Kuhlman, Computational Design of the Sequence and Structure of a Protein-Binding Peptide Journal of the American Chemical Society. ,vol. 133, pp. 4190- 4192 ,(2011) , 10.1021/JA110296Z
Marc Feldmann, Lawrence Steinman, Design of effective immunotherapy for human autoimmunity Nature. ,vol. 435, pp. 612- 619 ,(2005) , 10.1038/NATURE03727
Marc Feldmann, Ravinder N Maini, Lasker Clinical Medical Research Award. TNF defined as a therapeutic target for rheumatoid arthritis and other autoimmune diseases. Nature Medicine. ,vol. 9, pp. 1245- 1250 ,(2003) , 10.1038/NM939
J. Michael Kilby, Sam Hopkins, Thomas M. Venetta, Betty DiMassimo, Gretchen A. Cloud, Jeannette Y. Lee, Leslie Alldredge, Eric Hunter, Dennis Lambert, Dani Bolognesi, Thomas Matthews, M. Ross Johnson, Martin A. Nowak, George M. Shaw, Michael S. Saag, POTENT SUPPRESSION OF HIV-1 REPLICATION IN HUMANS BY T-20, A PEPTIDE INHIBITOR OF GP41-MEDIATED VIRUS ENTRY Nature Medicine. ,vol. 4, pp. 1302- 1307 ,(1998) , 10.1038/3293