Astrocyte reactivity to Fas activation is attenuated in TIMP-1 deficient mice, an in vitro study.
作者： Crystel Ogier , Rita Creidy , José Boucraut , Paul D Soloway , Michel Khrestchatisky
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摘要: Background Tissue inhibitor of metalloproteinases-1 (TIMP-1) is a multifunctional secreted protein with pleiotropic actions, including the inhibition matrix metalloproteinases (MMPs), cell death/survival and growth promoting activities. After inflammatory challenge, levels TIMP-1 are highly selectively upregulated in astrocytes among glial cells, but little know about its role these neural cells. We investigated influence null mutation reactivity cultured to pro-inflammatory stimuli TNF-α anti-Fas antibody.
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Soloway Pd, Werb Z, Alexander Cm, Jaenisch R, Targeted mutagenesis of Timp-1 reveals that lung tumor invasion is influenced by Timp-1 genotype of the tumor but not by that of the host. Oncogene. ,vol. 13, pp. 2307- 2314 ,(1996)
F. Mannello, G. Gazzanelli, Tissue inhibitors of metalloproteinases and programmed cell death: conundrums, controversies and potential implications. Apoptosis. ,vol. 6, pp. 479- 482 ,(2001) , 10.1023/A:1012493808790
Daniel Kitsberg, Etienne Formstecher, Mireille Fauquet, Miroslav Kubes, Jocelyne Cordier, Brigitte Canton, GuoHua Pan, Malvyne Rolli, Jacques Glowinski, Herve Chneiweiss, None, Knock-Out of the Neural Death Effector Domain Protein PEA-15 Demonstrates That Its Expression Protects Astrocytes from TNFα-Induced Apoptosis The Journal of Neuroscience. ,vol. 19, pp. 8244- 8251 ,(1999) , 10.1523/JNEUROSCI.19-19-08244.1999
Rudi Beyaert, Geert Van Loo, Karen Heyninck, Peter Vandenabeele, Signaling to gene activation and cell death by tumor necrosis factor receptors and Fas. International Review of Cytology-a Survey of Cell Biology. ,vol. 214, pp. 225- 272 ,(2002) , 10.1016/S0074-7696(02)14007-1
Pascale Giraudon, Raphaël Szymocha, Stéphanie Buart, Arlette Bernard, Luis Cartier, Marie-Françoise Belin, Hideo Akaoka, T Lymphocytes Activated by Persistent Viral Infection Differentially Modify the Expression of Metalloproteinases and Their Endogenous Inhibitors, TIMPs, in Human Astrocytes: Relevance to HTLV-I-Induced Neurological Disease The Journal of Immunology. ,vol. 164, pp. 2718- 2727 ,(2000) , 10.4049/JIMMUNOL.164.5.2718
Valérie Schnuriger, Philippe Saas, Anne-Lise Quiquerez, Gaelle Perrin, Pierre-Yves Dietrich, José Boucraut, Sophie Desplat-Jego, Paul R. Walker, Dominique Bernard, CD95 (Fas/Apo-1) as a receptor governing astrocyte apoptotic or inflammatory responses: a key role in brain inflammation? Journal of Immunology. ,vol. 162, pp. 2326- 2333 ,(1999)
Sung Joong Lee, Tong Zhou, Chulhee Choi, Zheng Wang, Etty N. Benveniste, Differential Regulation and Function of Fas Expression on Glial Cells The Journal of Immunology. ,vol. 164, pp. 1277- 1285 ,(2000) , 10.4049/JIMMUNOL.164.3.1277
C L Kincaid, A K Stalder, A Pagenstecher, I L Campbell, S D Shapiro, Differential expression of matrix metalloproteinase and tissue inhibitor of matrix metalloproteinase genes in the mouse central nervous system in normal and inflammatory states. American Journal of Pathology. ,vol. 152, pp. 729- 741 ,(1998)
Alicia A. Babcock, William A. Kuziel, Serge Rivest, Trevor Owens, Chemokine Expression by Glial Cells Directs Leukocytes to Sites of Axonal Injury in the CNS The Journal of Neuroscience. ,vol. 23, pp. 7922- 7930 ,(2003) , 10.1523/JNEUROSCI.23-21-07922.2003
Zezong Gu, Marcus Kaul, Boxu Yan, Steven J Kridel, Jiankun Cui, Alex Strongin, Jeffrey W Smith, Robert C Liddington, Stuart A Lipton, S-Nitrosylation of Matrix Metalloproteinases: Signaling Pathway to Neuronal Cell Death Science. ,vol. 297, pp. 1186- 1190 ,(2002) , 10.1126/SCIENCE.1073634