Signaling to gene activation and cell death by tumor necrosis factor receptors and Fas.

摘要: Abstract Tumor necrosis factor (TNF) receptors and Fas elicit a wide range of biological responses, including cell death, proliferation, inflammation, differentiation. The pleiotropic character these is reflected at the level signal transduction. cytotoxic effects TNF result from activation an apoptotic/necrotic program. On other hand, receptors, under certain conditions also Fas, exert proinflammatory function that results induction several genes. In this context, transcription nuclear factor-kappa B (NF-κB) plays important role. NF-κB for antiapoptotic genes, which explains least partially why types can only be killed by in presence or translation inhibitors. It balance between proapoptotic pathways determines whether will finally die proliferate. A third transduction pathway activated response to mitogen-activated protein kinase cascade, role modulation transcriptional gene activation.