Metzincin Proteases and their Inhibitors, Foes or Friends in Nervous System Physiology?

摘要: Members of the metzincin family metalloproteinases have long been considered merely degradative enzymes for extracellular matrix molecules. Recently, however, there has growing appreciation these proteinases and their endogenous inhibitors, tissue inhibitors (TIMPs), as fine modulators nervous system physiology pathology. Present all along phylogenetic tree, in neural cell types, from nucleus to synapse space, exhibit a complex spatiotemporal profile expression parenchyma at neurovascular interface. The irreversibility proteolytic activity on numerous biofactors (e.g., growth factors, cytokines, receptors, DNA repair enzymes, proteins) is ideally suited sustain structural changes that are involved physiological or postlesion remodeling networks, learning consolidation impairment, neurodegenerative neuroinflammatory processes, progression malignant gliomas. present review provides state art overview involvement metzincin/TIMP processes prospects new therapeutic strategies based control metalloproteinase activity.