Effect of Ganoderma lucidum on the activities of mitochondrial dehydrogenases and complex I and II of electron transport chain in the brain of aged rats.
作者： T.A. Ajith , N.P. Sudheesh , D. Roshny , G. Abishek , K.K. Janardhanan
DOI: 10.1016/J.EXGER.2008.11.002
关键词:
摘要: Abstract Dysfunction of the mitochondrial respiratory chain, being direct intracellular source reactive oxygen species (ROS), is important in pathogenesis number ageing associated human disorders. Effect ethanol extract Ganoderma lucidum on activities dehydrogenases; complex I and II electron transport chain have been evaluated aged rat brain. Aged male Wistar rats were administered with G. (50 250 mg/kg, p.o) once daily for 15 days. Similarly dl -α-lipoic acid (100 mg/kg, group was kept as reference standard. Young water young control, respectively. The effect treatment assessed by estimating succinate dehydrogenase (SDH), malate (MDH), α-ketoglutarate (α-KGDH), pyruvate (PDH), mitochondria Results study demonstrated that 250 mg/kg) significantly (p
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