Interaction between epidermal growth factor and its receptor in progression of human gastric carcinoma.
作者： Wataru Yasui , Jotaro Hata , Hiroshi Yokozaki , Hiroshi Nakatani , Atsushi Ochiai
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摘要: The expressions of epidermal growth factor (EGF) and its receptor were studied immunohistochemically in a total 156 gastric carcinomas; 26 early 130 advanced. No EGF immunoreactivity was found carcinomas, while EGF-positive tumor cells detected 38 (29.2%) the advanced carcinomas. one (3.8%) carcinomas 44 (33.8%) incidence being significantly different (p<0.01). Out 17 (13.1%) had synchronous expression most tumors with strong positive to receptor. A significant correlation observed between depth invasion or (p<0.05). Furthermore, good demonstrated staging. cases metastatic higher than that primary Patients far poorer prognosis those without
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