Postoperative analgesic effects of intravenous, intramuscular, subcutaneous or oral transmucosal buprenorphine administered to cats undergoing ovariohysterectomy.

作者: Tatiana Giordano , Paulo VM Steagall , Tatiana H Ferreira , Bruno W Minto , Sílvia Elaine Rodolfo De Sá Lorena

DOI: 10.1111/J.1467-2995.2010.00541.X

关键词:

摘要: Objective To compare the postoperative analgesic effects of intravenous (IV), intramuscular (IM), subcutaneous (SC) or oral transmucosal (OTM) buprenorphine administered to cats undergoing ovariohysterectomy. Study design Randomized, prospective and blinded clinical trial. Animals 100 female cats. Methods Cats were assigned receive 0.01 mg kg(-1) by IV, IM, SC OTM route (n = 25/group). Buprenorphine was made up 0.3 mL with 0.9% saline. DIVAS (0-100 mm) simple descriptive scale (SDS) (from 0 4) pain sedation scores each cat before 1, 2, 3, 4, 6, 8, 12 24 hours after carprofen for rescue analgesia. Data analyzed using anova Fisher's exact test (p Results There no significant differences between groups breed, body weight, anesthetic time surgery > 0.05). at any time. SDS did not detect administration significantly higher than IV IM 1 hour 8 hours, respectively Conclusions relevance provided better analgesia drug these routes should be preferred when is

参考文章(23)
P. M. Taylor, S. A. Robertson, M. J. Dixon, M. Ruprah, J. W. Sear, B. D. X. Lascelles, C. Waters, M. Bloomfield, Morphine, pethidine and buprenorphine disposition in the cat. Journal of Veterinary Pharmacology and Therapeutics. ,vol. 24, pp. 391- 398 ,(2002) , 10.1046/J.1365-2885.2001.368GOBLIN.X
I. Lizasoain, J.C. Leza, P. Lorenzo, Buprenorphine: Bell-shaped dose-response curve for its antagonist effects General Pharmacology: The Vascular System. ,vol. 22, pp. 297- 300 ,(1991) , 10.1016/0306-3623(91)90452-C
L. S. Slingsby, A. E. Waterman-Pearson, Postoperative analgesia in the cat after ovariohysterectomy by use of carprofen, ketoprofen, meloxicam or tolfenamic acid Journal of Small Animal Practice. ,vol. 41, pp. 447- 450 ,(2000) , 10.1111/J.1748-5827.2000.TB03139.X
John Mendelson, Robert A. Upton, E. Thomas Everhart, Peyton Jacob III, Reese T. Jones, Bioavailability of Sublingual Buprenorphine The Journal of Clinical Pharmacology. ,vol. 37, pp. 31- 37 ,(1997) , 10.1177/009127009703700106
B. D. X. Lascelles, C. A. Capner, A. E. Waterman-Pearson, Current British veterinary attitudes to perioperative analgesia for cats and small mammals Veterinary Record. ,vol. 145, pp. 601- 604 ,(1999) , 10.1136/VR.145.21.601
S. A. ROBERTSON, B. D. X. LASCELLES, P. M. TAYLOR, J. W. SEAR, PK-PD modeling of buprenorphine in cats: intravenous and oral transmucosal administration Journal of Veterinary Pharmacology and Therapeutics. ,vol. 28, pp. 453- 460 ,(2005) , 10.1111/J.1365-2885.2005.00677.X
Sheilah A. Robertson, Kirsten Wegner, Benedict Duncan X. Lascelles, Antinociceptive and side-effects of hydromorphone after subcutaneous administration in cats. Journal of Feline Medicine and Surgery. ,vol. 11, pp. 76- 81 ,(2009) , 10.1016/J.JFMS.2008.05.003
Paulo V.M. Steagall, Fernanda B. Mantovani, Polly M. Taylor, Mike J. Dixon, Stelio P.L. Luna, Dose-related antinociceptive effects of intravenous buprenorphine in cats. Veterinary Journal. ,vol. 182, pp. 203- 209 ,(2009) , 10.1016/J.TVJL.2008.06.017
Paulo VM Steagall, Polly M Taylor, Juliana T Brondani, Stelio PL Luna, Mike J Dixon, Tatiana H Ferreira, Effects of buprenorphine, carprofen and saline on thermal and mechanical nociceptive thresholds in cats Veterinary Anaesthesia and Analgesia. ,vol. 34, pp. 344- 350 ,(2007) , 10.1111/J.1467-2995.2006.00331.X
PVM Steagall, P Carnicelli, PM Taylor, Stélio Pacca Loureiro Luna, M Dixon, TH Ferreira, Effects of subcutaneous methadone, morphine, buprenorphine or saline on thermal and pressure thresholds in cats Journal of Veterinary Pharmacology and Therapeutics. ,vol. 29, pp. 531- 537 ,(2006) , 10.1111/J.1365-2885.2006.00800.X