Antinociceptive and side-effects of hydromorphone after subcutaneous administration in cats.
作者： Sheilah A. Robertson , Kirsten Wegner , Benedict Duncan X. Lascelles
DOI: 10.1016/J.JFMS.2008.05.003
关键词:
摘要: The subcutaneous (SC) route is often chosen for drug administration in cats because it easier to perform than intravenous (IV) injection and perceived as less painful intramuscular (IM) injection. However, little known of how the influences pharmacodynamics drugs. This study measured changes skin temperature thermal threshold (TT) recorded side-effects after SC 0.1 mg/kg hydromorphone six cats. Time peak TT was 105 min. Skin elevated at 15 min between 45 360 min. Five vomited two exhibited marked dysphoria. Compared previously published studies IV IM hydromorphone, results a slower onset effect, shorter duration antinociception associated with more undesirable side-effects. As injections, significant elevation temperature. Overall, appears have least utility.
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