Marek's Disease Virus Influences the Expression of Genes Associated with IFN-γ-Inducible MHC Class II Expression
作者： Niroshan Thanthrige-Don , Leah R. Read , Mohamed Faizal Abdul-Careem , Hakimeh Mohammadi , Amirul I. Mallick
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摘要: Abstract Chickens infected with Marek's disease virus (MDV) become lifelong carriers regardless of their susceptibility to clinical disease. Therefore various viral immune-evasive mechanisms must play a role in MDV-host interactions. MDV has previously been shown influence the expression major histocompatibility complex (MHC) class II molecules. However, little is known about underlying this phenomenon. In present study, we studied effect infection on several genes associated IFN-γ-inducible MHC at 4, 7, 14, and 21 days post-infection (dpi). There was significant (p ≤ 0.05) downregulation β chain throughout experiment, while other components heterotrimer (i.e., α invariant chain) were significantly downregulated only 4 dpi. Furthermore, IFN-γ-receptor contrast, ...
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