The relationship between lymphovascular invasion and angiogenesis, hormone receptors, cell proliferation and survival in patients with primary operable invasive ductal breast cancer

摘要: Several well-established tumour prognostic factors are used to guide the clinical management of patients with breast cancer. Lymphovascular invasion and angiogenesis have also been reported some promise as factors. The aim present study was examine value lymphovascular microvessel density compared that established in invasive ductal In addition hormone receptor status Ki-67 proliferative activity, their relationship survival were examined Full sections tissue microarrays (n = 384 patients) utilised assess these scored by appropriate methods. On univariate analysis size (P < 0.05), lymph node involvement (P < 0.01), (P < 0.05) local- regional treatment (P < 0.01) associated poorer ER negative tumours. multivariate tumours independently cancer-specific survival. grade (P < 0.001), HER-2 (P < 0.001) positive but not