Breast cancer outcomes by steroid hormone receptor status assessed visually and by computer image analysis.

摘要: Mohammed Z M A, Edwards J, Orange C, Mallon E, Doughty J McMillan D C & Going (2012) Histopathology 61, 283–292 Breast cancer outcomes by steroid hormone receptor status assessed visually and computer image analysis Aims:  To compare the assessment of immunohistochemistry eye computer-aided analysis, to examine their relationships with survival in breast cancer. Methods results:  Allred scores weighted histoscores for oestrogen (ER) progesterone (PR) were determined (visual histoscore) 459 primary invasive ductal carcinomas triplicate tissue microarrays. Histoscores also computerized analysis (automated histoscore). ER PR these different methods compared each other ability predict over at least 142 months follow-up. visual histoscore highly associated (both P < 0.001). By univariate score recurrence-free cancer-specific P < 0.001) patients overall, those who received tamoxifen, recurrence on tamoxifen. Visual automated excellent agreement P < 0.001), equally effective predicting tamoxifen. Conclusions:  Automated appears be a valid alternative or determining status.