Interference of nonsense mutations with eukaryotic messenger RNA stability
作者： R. Losson , F. Lacroute
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摘要: The fine structure map of the yeast URA 3 gene was established by meiotic recombination, and amber nonsense mutations were located at different points on map. effect length labeling time specific radioactivity ura messenger RNA its repartition between poly(A)-RNA not containing poly(A) has been followed in mutants. Nonsense reduce level without lowering instantaneous rate synthesis. strength reduction depends position codon within locus concerns essentially accumulation polyadenylylated mRNA.
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