A randomized double-blind study to compare the effects of nasal fluticasone and betamethasone on the hypothalamo-pituitary-adrenal axis and bone turnover in patients with nasal polyposis

摘要: Treatment of nasal polyposis with topical betamethasone is associated suppression the hypothalamo-pituitary-adrenal (HPA) axis and, potentially, has adverse effects on bone turnover. Fluticasone propionate a potent corticosteroid negligible absorption across mucosa and extensive first-pass hepatic metabolism. We performed randomized double-blind study, in patients polyposis, comparing 8 weeks' treatment drops or fluticasone nasules HPA using 1 micro g tetracosactide test, turnover two serum markers. Nine were allocated to each treatment. Betamethasone resulted significant test (P = 0.006), but did not 0.113). There no differences efficacy between treatments. drops, nasules, suppresses given comparable efficacy, administered via nasule should be preferred agent.