Liver X receptor agonist T0901317 reverses resistance of A549 human lung cancer cells to EGFR-TKI treatment.
作者： Haixia Cao , Shaorong Yu , Dan Chen , Changwen Jing , Zhuo Wang
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摘要: Epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) is effective in lung cancer patients carrying sensitive EGFR mutations. In this study, we investigated if liver X receptor (LXR) agonist T0901317 could reverse the resistance of cell lines A549 and H1650 to EGFR-TKI treatment. We found that make natural EGFR-TKI-resistant human cells treatment was dependent on LXRβ expression. However, does not have a similar effect another line H1650.
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