Prooxidant action of maltol: role of transition metals in the generation of reactive oxygen species and enhanced formation of 8-hydroxy-2'-deoxyguanosine formation in DNA.
作者： Keiko Murakami , Kumiko Ishida , Kyoko Watakabe , Ryoko Tsubouchi , Miyako Haneda
DOI: 10.1007/S10534-005-6998-Y
关键词:
摘要: Maltol (3-hydroxy-2-methyl-4-pyrone) produced reactive oxygen species as a complex with transition metals. Maltol/iron inactivated aconitase the most sensitive enzyme to oxidative stress. The inactivation of was iron-dependent, and prevented by TEMPOL, scavenger species, suggesting that maltol/iron-mediated generation superoxide anion is responsible for aconitase. Addition maltol effectively enhanced ascorbate/copper-mediated formation 8-hydroxy-2′-deoxyguanosine in DNA. Oxidation ascorbic acid CuSO4 stimulated addition maltol, oxidation rate markedly inhibited catalase dismutase. These results suggest can stimulate copper reduction coupled ascorbate, resulting production radical which turn converts hydrogen peroxide hydroxyl radical. Cytotoxic effect be explained its prooxidant properties: maltol/transition metal generates causing DNA base adduct.
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