Prooxidant action of rhodizonic acid: transition metal-dependent generation of reactive oxygen species causing the formation of 8-hydroxy-2'-deoxyguanosine formation in DNA.
作者： Keiko Murakami , Miyako Haneda , Makoto Naruse , Masataka Yoshino
DOI: 10.1016/J.TIV.2006.01.009
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摘要: Abstract Rhodizonic acid, a six-membered cyclic hydroxyquinone, produced reactive oxygen species as complex with transition metals. Addition of rhodizonic acid ferrous ion caused an inactivation aconitase the most sensitive enzyme to oxidative stress in permeabilized yeast cells. The iron-dependent implies acid/iron-mediated generation species. Spectrophotometric analysis interaction FeSO4 showed that addition superoxide dismutase could inhibit oxidation suggesting from is radical. further acted prooxidant causing copper-dependent DNA damage. Treatment plasmid pBR322 and calf thymus plus copper strand scission formation 8-hydroxy-2′-deoxyguanosine DNA. catalase protected acid-mediated scission, indicating hydroxyl radical may participate also potent copper-reducing activity. These results indicate reduced by converts hydrogen peroxide Other hydroxyquinones such four-membered squaric five-membered croconic did not show any reducing effects. Cytotoxic effects tetrahydroquinone precursor be related properties formed
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