Na+Ca2+ exchange current: lack of effect of taurine
作者： Yasuhiro Katsube , Nicholas Sperelakis
DOI: 10.1016/S0014-2999(96)00652-8
关键词:
摘要: The intracellular taurine content is very high in some types of cells, including myocardial and becomes depleted failing hearts. effect on inward (forward) outward (reversal) Na+/Ca2+ exchange current (INa/Ca) was examined freshly isolated rat (11-20-day-old) ventricular cells using whole-cell voltage clamp. INa/Ca evoked by a 300 ms ramp hyperpolarizing pulse at rate 0.67 V/s (from +60 to -140 mV) from holding potential -40 mV. Under the condition 500 nM Ca2+ pipette, when bath solution changed 150 mM Li+ Na+, an initiated. On other hand, under 50 Na+ 56 Na(+)-free, Ca(2+)-free 2 Ca2+, Both were completely blocked 5 Ni2+, helping identify as INa/Ca. Forward reversal measured absence (control) presence 30 added bath. densities (pA/pF) -50 mV 0.75 +/- 0.12 control 0.73 0.11 taurine. Outward +50 0.08 0.65 0.02 There no significant differences between for both Therefore, various effects reported heart are not caused direct Na/Ca exchange.
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