Neoadjuvant therapy of high-risk gastric cancer: a phase II trial of preoperative FAMTX and postoperative intraperitoneal fluorouracil-cisplatin plus intravenous fluorouracil.
作者： D Kelsen , M Karpeh , G Schwartz , H Gerdes , C Lightdale
DOI: 10.1200/JCO.1996.14.6.1818
关键词:
摘要: PURPOSE AND METHODSWe identified patients with gastric cancer at high risk for recurrence before therapy using endoscopic ultrasonography (EUS). Neoadjuvant the fluorouracil, doxorubicin, and metrotrexate (FAMTX) regimen was given three courses planned laparotomy intention to perform curative resection. Postoperatively, intraperitoneal (IP) cisplatin fluorouracil (FU) intravenous (i.v.) FU were administered undergoing resection.RESULTSFifty-six assessable treated. Preoperative FAMTX tolerable, major toxicity being neutropenic fever. One treatment-related death seen. Eighty-nine percent of underwent surgical exploration 61% had potentially resections. There two postoperative deaths. Comparison pathologic tumor (pT) stage EUS-predicted showed apparent downstaging in 51% patients. Postoperative IP chemotherapy delivered 75% eligible Toxicity ac...
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