Regulation of hyphal morphogenesis by Ras and Rho small GTPases
作者： Robert A. Arkowitz , Martine Bassilana
DOI: 10.1016/J.FBR.2015.02.003
关键词:
摘要: Abstract The fungal kingdom is extremely diverse – comprised of over 1.5 million species including yeasts, molds and mushrooms. Essentially, all fungi have cell walls that contain chitin the cells most grow as tube-like filaments called hyphae. These filamentous fungi, such mold Neurospora crassa , develop branched radial networks hyphae referred to mycelium. In contrast, non-filamentous do not form mycelia, but single cells, which reproduce by either budding or fission Saccharomyces cerevisiae Schizosaccharomyces pombe respectively. Finally, there are capable switching between cell, yeast growth Candida albicans . switch from in these so-called dimorphic a virulence trait many human plant pathogens. Highly conserved master regulators three modes filamentous, Ras Rho small GTPases, spatially temporally control polarity establishment maintenance. This review summarizes key roles GTPases during hyphal morphogenesis range fungi.
elsevier.com
sci-hub.se 参考文章(177)
Luca Goitre, Eliana Trapani, Lorenza Trabalzini, Saverio Francesco Retta, The Ras Superfamily of Small GTPases: The Unlocked Secrets Methods in Molecular Biology. ,vol. 1120, pp. 1- 18 ,(2014) , 10.1007/978-1-62703-791-4_1
Sonja Michel, Sophia Ushinsky, Bert Klebl, Ekkehard Leberer, David Thomas, Malcolm Whiteway, Joachim Morschhäuser, Generation of conditional lethal Candida albicans mutants by inducible deletion of essential genes Molecular Microbiology. ,vol. 46, pp. 269- 280 ,(2002) , 10.1046/J.1365-2958.2002.03167.X
Terry Roemer, Bo Jiang, John Davison, Troy Ketela, Karynn Veillette, Anouk Breton, Fatou Tandia, Annie Linteau, Susan Sillaots, Catarina Marta, Nick Martel, Steeve Veronneau, Sebastien Lemieux, Sarah Kauffman, Jeff Becker, Reginald Storms, Charles Boone, Howard Bussey, Large‐scale essential gene identification in Candida albicans and applications to antifungal drug discovery Molecular Microbiology. ,vol. 50, pp. 167- 181 ,(2003) , 10.1046/J.1365-2958.2003.03697.X
Karl Dichtl, Christoph Helmschrott, Franziska Dirr, Johannes Wagener, Deciphering cell wall integrity signalling in Aspergillus fumigatus: identification and functional characterization of cell wall stress sensors and relevant Rho GTPases Molecular Microbiology. ,vol. 83, pp. 506- 519 ,(2012) , 10.1111/J.1365-2958.2011.07946.X
Michael Mahlert, Leonora Leveleki, Andrea Hlubek, Björn Sandrock, Michael Bölker, Rac1 and Cdc42 regulate hyphal growth and cytokinesis in the dimorphic fungus Ustilago maydis. Molecular Microbiology. ,vol. 59, pp. 567- 578 ,(2006) , 10.1111/J.1365-2958.2005.04952.X
J Wendland, P Philippsen, Cell polarity and hyphal morphogenesis are controlled by multiple rho-protein modules in the filamentous ascomycete Ashbya gossypii. Genetics. ,vol. 157, pp. 601- 610 ,(2001) , 10.1093/GENETICS/157.2.601
Timo Schürg, Ulrike Brandt, Christian Adis, André Fleißner, The Saccharomyces cerevisiae BEM1 homologue in Neurospora crassa promotes co-ordinated cell behaviour resulting in cell fusion Molecular Microbiology. ,vol. 86, pp. 349- 366 ,(2012) , 10.1111/J.1365-2958.2012.08197.X
Hannah Hope, Christian Schmauch, Robert A. Arkowitz, Martine Bassilana, The Candida albicans ELMO homologue functions together with Rac1 and Dck1, upstream of the MAP Kinase Cek1, in invasive filamentous growth Molecular Microbiology. ,vol. 76, pp. 1572- 1590 ,(2010) , 10.1111/J.1365-2958.2010.07186.X
Charles F. Albright, Kathleen E. Mach, Kyle A. Furge, Loss of Rhb1, a Rheb-related GTPase in fission yeast, causes growth arrest with a terminal phenotype similar to that caused by nitrogen starvation. Genetics. ,vol. 155, pp. 611- 622 ,(2000) , 10.1093/GENETICS/155.2.611
Kylie J. Boyce, Michael J. Hynes, Alex Andrianopoulos, The Ras and Rho GTPases genetically interact to co-ordinately regulate cell polarity during development in Penicillium marneffei Molecular Microbiology. ,vol. 55, pp. 1487- 1501 ,(2005) , 10.1111/J.1365-2958.2005.04485.X