Combined cyclotron fast-neutron and BCNU therapy in a rat brain-tumor model
作者： Alexander M. Spence , Joseph P. Geraci
DOI: 10.3171/JNS.1981.54.4.0461
关键词:
摘要: The combination of cyclotron fast-neutron radiotherapy with BCNU chemotherapy was compared to 137Cs gamma photon combined in the 36B-10, F-344 rat-transplanted glioma model. Radiation and drug treatments were administered 7 8 days after intracerebral tumor implantation. Increase animal survival time used as measure effectiveness various treatment schedules. Single-dose neutron or tested on Day over ranges 0 900 rads 2000 rads, respectively. This therapy produced increases mean times up 70% at highest radiation doses. When (10 mg/kg body weight) intravenously 8, 1 day following radiotherapy, increased by an additional 35% 50%, irrespective dose type irradiation. In contrast, using same doses but scheduling trials so that hour before either irradiation 7, there enhancement effect BCNU. Under these conditions, maximum 75% neutron-treated animals 120% 150% gamma-treated animals. Treatment proved be no more effective proving tumor-bearing than similarly conventional
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