The α7 nicotinic acetylcholine receptor function in hippocampal neurons is regulated by the lipid composition of the plasma membrane.
作者： José O. Colón-Sáez , Jerrel L. Yakel
DOI: 10.1113/JPHYSIOL.2011.209494
关键词:
摘要: Non-technical summary The α7 nicotinic acetylcholine receptors (nAChRs) are a therapeutic target for the treatment of neurological disorders such as Alzheimer's disease and schizophrenia, drugs that potentiate nAChRs through regulation desensitization currently being developed. Here we show changes to lipid composition plasma membrane in rat hippocampal neurons, either acute with remove cholesterol breakdown sphingomyelin or chronic synthesis inhibitors sphingomyelin, result significant nAChRs. These data provide evidence is able modulate nAChRs, which will be important development new reagents. Abstract play an role cellular events neurotransmitter release, second messenger cascades, cell survival apoptosis. In addition, they Recently, these channels were found localized into rafts. disruption rafts primary cholesterol-scavenging (methyl-β-cyclodextrin) enzymatic (sphingomyelinase), results kinetics native expressed effects can prevented by cotreatment mimicked (mevastatin myriocin, respectively), suggesting on indeed due levels membrane. insights mechanism providing activity
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