The immune complex: possible ways of regulating the antibody response

作者: Birgitta Heyman

DOI: 10.1016/0167-5699(90)90126-T

关键词:

摘要: B cells express antigen, Fc and complement receptors on their surfaces can thus bind all three components of an immune complex. In addition to the direct effects that they exert cells, complexes may affect localization, presentation digestion antigen. this article, Birgitta Heyman discusses recent developments in antibody-mediated regulation humoral response, with emphasis vivo systems where antigens are injected together highly purified IgM or IgG antibodies absence adjuvants.

参考文章(85)
F. Enriquez-Rincon, G. G. B. Klaus, Differing effects of monoclonal anti-hapten antibodies on humoral responses to soluble or particulate antigens. Immunology. ,vol. 52, pp. 129- 136 ,(1984)
Mary K. Kuhner, Johnny Ludvigsson, Wendy P. Robinson, Ingeborg Deschamps, Bertil Lindblom, Edith Schober, Glenys Thomson, Sharon Joe, Jose Barbosa, Jukka Partanen, Michael J. MacDonald, Brian D. Tait, Jerome L. Gottschall, Wolfgang R. Mayr, Stephen S. Rich, Nadir R. Farid, Christine Thompson, Jörg Bertrams, Max P. Baur, Genetic heterogeneity, modes of inheritance, and risk estimates for a joint study of caucasians with insulin-dependent diabetes mellitus American Journal of Human Genetics. ,vol. 43, pp. 799- 816 ,(1988)
G Del Prete, A Tiri, P Parronchi, S Romagnani, M De Carli, D Macchia, C Simonelli, E Maggi, M Ricci, P Biswas, Noncognate contact-dependent B cell activation can promote IL-4-dependent in vitro human IgE synthesis. Journal of Immunology. ,vol. 144, pp. 2102- 2108 ,(1990)
John W. Kappler, Umarani Dharmarajan, Michael Hoffmann, André van der Hoven, Regulation of the Immune Response IV. Antibody-Mediated Suppression of the Immune Response to Haptens and Heterologous Erythrocyte Antigens in Vitro Journal of Immunology. ,vol. 111, pp. 1228- 1235 ,(1973)
E A Ottesen, T B Nutman, A S Withers, In vitro parasite antigen-induced antibody responses in human helminth infections. Journal of Immunology. ,vol. 135, pp. 2794- 2799 ,(1985)
I Chrétien, J Banchereau, J E De Vries, J Pène, F Rousset, F Brière, X Paliard, H Spits, IgE production by normal human B cells induced by alloreactive T cell clones is mediated by IL-4 and suppressed by IFN-gamma. Journal of Immunology. ,vol. 141, pp. 1218- 1224 ,(1988)
J Carty, R L Coffman, A Zlotnik, J Ohara, W E Paul, M W Bond, B cell stimulatory factor-1 enhances the IgE response of lipopolysaccharide-activated B cells. Journal of Immunology. ,vol. 136, pp. 4538- 4541 ,(1986)