Chemoradiation therapy: effect on dental development.

摘要: Chemoradiation therapy used on pediatric oncology patients often causes dental developmental anomalies that affect future care. Defects noted include tooth and root agenesis, thinning shortening, localized enamel defects. Histologically, these defects appear as osteoid-like niches in the developing dentin which alter overlying enamel. Odontogenic cell sensitivity is dependent upon position cycle mitotic activity at time of chemoradiation therapy. Knowledge stage development treatment type allows clinician to predict effects chemoradiation. Representative cases illustrate clinical manifestations dentition.