Epigenetic theories of cancer initiation.
作者： Lionel F. Jaffe
DOI: 10.1016/S0065-230X(03)90007-8
关键词:
摘要: I argue that carcinogenic insults injure many cells rather than mutate a few. This results from evidence such convert too to precancerous state and of the converted then revert plausibly involve mutation its repair; delays between chemically demonstrable mutations are long enough easily allow nonmutational mechanisms work; even ionizing radiation first acts on cytoplasm mainly affects unhit by it; fact induce proto-oncogene expression far quickly do so mutation; fusions various cell parts show tumorous or nontumorous nature product depends cytoplasmic nuclear component. further reduced DNA methylation, modifications histone code, tissue disorganization three main epigenetic cancer initiation. Hypomethylation would result excision repair. Moreover, methyl-deficient diet is demethylation also known be via code. Finally, strongly for as mechanism skin carcinogens disrupt dermal/epidermal connection tumorigens swiftly gap junctions, well disruption tumorigenic.
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