LncRNA PAINT is Associated with Aggressive Prostate Cancer and Dysregulation of Cancer Hallmark Genes
作者： Julia N Soulakova , Ratna Chakrabarti , Domenico Coppola , Wei Zhang , Faqrul Hasan
DOI: 10.1002/IJC.33569
关键词:
摘要: Long non-coding RNAs (lncRNAs) play regulatory role in cellular processes and their aberrant expression may drive cancer progression. Here we report the function of a lncRNA PAINT (Prostate Cancer Associated Intergenic Non-Coding Transcript) promoting prostate (PCa) Upregulation was noted advanced stage metastatic PCa. Inhibition decreased cell proliferation, S-phase progression, increased apoptotic markers, improved sensitivity to docetaxel Aurora kinase inhibitor VX-680. migration reduced Slug Vimentin. Ectopic suppressed E-cadherin, progression migration. PCa cells induced larger colony formation, tumor growth higher mesenchymal markers. Transcriptome analysis followed by qRT-PCR validation showed differentially expressed genes involved epithelial transition (EMT), apoptosis drug resistance PAINT-expressing cells. Our study establishes an oncogenic
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