Effects of ascorbic acid and indomethacin on the airways of healthy male subjects with and without induced bronchoconstriction.
作者： C OGILVY , A DUBOIS , J DOUGLAS
DOI: 10.1016/0091-6749(81)90081-6
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摘要: Abstract We have investigated the effects of ascorbic acid (1.0 gm orally) and indomethacin (50 mg on airway tone in basal state six healthy nonsmoking male adults. Airway was assessed from measurements specific conductance flow rates interpolated partial expiratory flow-volume curves by means whole-body plethysmography spirometry, respectively. Neither nor alone produced a significant change tone. However, both duration intensity bronchoconstriction induced methacholine aerosol (10 mg/ml for 30 sec) were significantly reduced prior administration acid. This ameliorating action blocked ingestion indomethacin. The results suggest that exerts its altering production bronchodilator prostaglandin.
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