Trichosanthin affects HSV-1 replication in Hep-2 cells.
作者： Dong-Xu He , Siu-Cheung Tam
DOI: 10.1016/J.BBRC.2010.10.080
关键词:
摘要: Trichosanthin (TCS) is a type I ribosome-inactivating protein that inhibits the replication of both human immunodeficiency virus 1 (HIV-1) and herpes simplex (HSV-1). The mechanism inhibition not clear. This investigation explored effects TCS on stages HSV-1 infection in Hep-2 cells, from attachment to release. We demonstrated reduced antigen DNA content interfered with viral as early 3-15 h after infection. had no effect attachment, penetration or immediate-early gene expression. However, expression late genes virion release were diminished. In summary, this study demonstrates primarily affects cells during period.
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