Cytochrome P450 induction in Ictalurus punctatus following exposure to wastewater treatment plant effluent.
作者： Alicia Whatley , Paul M. Stewart , Smriti Subedi Bhattarai , Christi Magrath
DOI: 10.1080/14634980902908548
关键词:
摘要: Induction of the cytochrome P450 enzymes in fish, measured as ethoxyresorufin-O-deethylase (EROD) activity, has been extensively used a biomarker assessing exposures and responses aquatic organisms to contaminants. This study focused on whether exposure Troy (Alabama) wastewater treatment plant (TWWTP) effluent at Walnut Creek mixing zone, induced transcription mRNA for P4501A1 enzyme production increased EROD activity channel catfish (Ictalurus punctatus). Water from Big (Barbour County, AL), regarded least impacted by pollutants, was reference source administration positive control chemical (PCB – Aroclor 1254). All water samples were transported field sites University laboratory conducting study. Reverse transcriptase-polymerase chain reaction (RT-PCR) indicated presence compounds capable inducing CYP1A1 liver. Increased enzyme...
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