Targeting Vascular Endothelial Growth Factor in Advanced Carcinoid Tumor: A Random Assignment Phase II Study of Depot Octreotide With Bevacizumab and Pegylated Interferon Alfa-2b
作者： James C Yao , Alexandria Phan , Paulo M Hoff , Helen X Chen , Chusilp Charnsangavej
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摘要: Purpose Effective systemic therapy for advanced carcinoid is lacking. The combination of bevacizumab (BEV) and pegylated (PEG) interferon alfa-2b was evaluated among patients with metastatic or unresectable tumors. Patients Methods Forty-four on stable doses octreotide were randomly assigned to 18 weeks treatment PEG alfa-2b. At disease progression (PD) at the end (whichever occurred earlier), received plus until progression. Functional computer tomography (CT) scans performed measure effect tumor blood flow. Results In arm, four (18%) achieved confirmed partial response (PR), 17 (77%) had (SD), one patient (5%) PD. 15 (68%) SD six (27%) Progression-free survival (PFS) rates after monotherapy 95% in versus 68% arm. ...
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