Secondary acute myeloid leukemia in children previously treated with alkylating agents, intercalating topoisomerase II inhibitors, and irradiation.

摘要: PURPOSEPatient records were reviewed to identify cases of secondary acute myeloid leukemia (AML) with clinical and cytogenetic features characteristic classic epipodophyllotoxin-related AML in patients whose prior treatment for cancer did not include these agents.PATIENTS AND METHODSFour chromosomal abnormalities involving bands 11q23 21q22, the absence etoposide or teniposide, identified among treated at St Jude Children's Research Hospital between January 1980 April 1992.RESULTSThe four initially rhabdomyosarcoma, non-Hodgkin's lymphoma (n = 2), Hodgkins' disease. Prior chemotherapy included relatively low cumulative doses doxorubicin (median, 150 mg/m2; range, 120 375 mg/m2) cyclophosphamide 3,100 2,250 11,400 mg/m2). All had received radiation therapy: 59.4 Gy right middle ear rhabdomyosarcoma; 15 12 abdom...