The effect of direct steric interaction between substrate substituents and ligand substituents on enantioselectivities in asymmetric addition of diethylzinc to aldehydes catalyzed by sterically congested ferrocenyl aziridino alcohols
作者： Min-Can Wang , Xue-Hui Hou , Chao-Xian Chi , Ming-Sheng Tang
DOI: 10.1016/J.TETASY.2006.07.028
关键词:
摘要: Abstract The direct strong steric interaction between substrate substituents and ligand was first discovered in asymmetric addition of diethylzinc to aldehydes catalyzed by sterically congested ferrocenyl aziridino alcohol derivatives. In addition, this nonbonded repulsion influenced significantly enantioselectivities reaction, even led inversion the absolute configuration. This fact further confirmed theoretical calculations design a new chiral ligand. A plausible mechanism for reaction also proposed.
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sci-hub.se 参考文章(23)
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