Herpes zoster myelitis. Evidence for viral invasion of spinal cord.

摘要: Left thoracic herpes zoster in a 59-year-old woman was succeeded by myelopathy ascending saltatory manner over ten weeks until death occurred pulmonary embolus. Dexamethasone therapy instituted days after the rash began. Pathologic findings were those of unicentric and progressive gangliomyelopathy with cicatrization left T-8 dorsal root ganglion complete necrosis spinal cord from to T-11 serpentine extension caudally L-5 rostrally C3. Cowdry type A intranuclear inclusion bodies structures glial cells consistent nucleocapsids ofHerpesviruswere observed cervical cord.Herpesvirus varicella(VZ virus) isolated identified cord. The suggest that myelitis is mediated direct viral invasion cell lysis.