Effect of calcium channel blockers on the sensitivity of preoperative 99mTc-MIBI SPECT for hyperparathyroidism.
作者： Kent Friedman , Helina Somervell , Pavni Patel , Genevieve B. Melton , Elizabeth Garrett-Mayer
DOI: 10.1016/J.SURG.2004.06.047
关键词:
摘要: Background Technetium 99m ( Tc)-methoxyisobutylisonitrile (MIBI) single photon emission computed tomography (SPECT) is frequently used in the evaluation of patients with hyperparathyroidism. Calcium channel blockers (CACBs) may affect Tc-MIBI uptake by parathyroid cells. This study examines effect CACB therapy on sensitivity SPECT localization for Methods Two hundred fifty-three operated hyperparathyroidism were retrospectively reviewed. The potential scan was examined using logistic regression analysis. Possible confounding factors considered. Results Among 235 patients, those multiple endocrine neoplasia, type I (MEN-I), MEN-IIA, 4-gland hyperplasia, secondary hyperparathyroidism, and tertiary exhibited no difference associated use. Of remaining 198 primary 7/30 (23%) negative scans compared to 24/168 (14%) positive CACBs. After correcting age, gender gland weight, odds ratio (OR) a taking CACBs 2.88 (95% CI, 1.03-8.10; P = .045). Atherosclerosis, hypertension, diabetes mellitus, preoperative calcium hormone levels, thyroid use not factors. Conclusions reduces Further studies are required determine reversibility this termination therapy.
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utsystem.edu参考文章(18)
Manesh Parikshak, Gary B Talpos, Mark F Conrad, Eduardo D Castillo, Impact of hypercalcemia and parathyroid hormone level on the sensitivity of preoperative sestamibi scanning for primary hyperparathyroidism. American Surgeon. ,vol. 69, pp. 393- 399 ,(2003)
Adam C Berger, Steven K Libutti, David L Bartlett, Monica G Skarulis, Stephen J Marx, Allen M Spiegel, John L Doppman, H.Richard Alexander, Heterogeneous gland size in sporadic multiple gland parathyroid hyperplasia. Journal of The American College of Surgeons. ,vol. 188, pp. 382- 389 ,(1999) , 10.1016/S1072-7515(98)00317-2
Peter Ridefelt, Per Hellman, Jonas Rastad, Rolf Larsson, Göran Akersrröm, Erik Gylfe, Effects of calcium channel modulators on the regulation of cytoplasmic Ca2+ and hormone secretion of parathyroid cells. Pharmacology & Toxicology. ,vol. 78, pp. 147- 153 ,(1996) , 10.1111/J.1600-0773.1996.TB00196.X
A.Cahid Civelek, Elcin Ozalp, Patricia Donovan, Robert Udelsman, Prospective evaluation of delayed technetium-99m sestamibi SPECT scintigraphy for preoperative localization of primary hyperparathyroidism. Surgery. ,vol. 131, pp. 149- 157 ,(2002) , 10.1067/MSY.2002.119817
Bradford K. Mitchell, Eugene A. Cornelius, Sami Zoghbi, John R. Murren, Rola Ghoussoub, Stuart D. Flynn, Barbara K. Kinder, Mechanism of technetium 99m sestamibi parathyroid imaging and the possible role of p-glycoprotein. Surgery. ,vol. 120, pp. 1039- 1045 ,(1996) , 10.1016/S0039-6060(96)80052-3
Richard E. Royal, Ebrahim S. Delpassand, Suzanne E. Shapiro, Herbert A. Fritsche, Rena Vassilopoulou-Sellin, Steven I. Sherman, Robert F. Gagel, Douglas B. Evans, Jeffrey E. Lee, Improving the yield of preoperative parathyroid localization: technetium Tc 99m-sestamibi imaging after thyroid suppression. Surgery. ,vol. 132, pp. 968- 975 ,(2002) , 10.1067/MSY.2002.128609
Ali S Arbab, Kiyoshi Koizumi, Keiji Toyama, Takao Arai, Tsutomu Araki, None, Effects of ion channel modulators in the influx and efflux of Tc-99m-MIBI Annals of Nuclear Medicine. ,vol. 13, pp. 27- 32 ,(1999) , 10.1007/BF03165424
Satoshi Yamaguchi, M.D., Ph.D., Sunao Yachiku, M.D., Ph.D, Hiroshi Hashimoto, M.D., Ph.D., Shigeo Kaneko, M.D., Ph.D., Masayuki Nishihara, M.D., Daisuke Niibori, M.D., Noriyuki Shuke, M.D., Ph.D., Tamio Aburano, M.D., Ph.D., Relation between technetium 99m-methoxyisobutylisonitrile accumulation and multidrug resistance protein in the parathyroid glands. World Journal of Surgery. ,vol. 26, pp. 29- 34 ,(2002) , 10.1007/S00268-001-0177-2
Nancy A. Obuchowski, Angelo A. Licata, Eric Q. Chen, Donald R. Neumann, Caldwell B. Esselstyn, Raymundo T. Go, William J. MacIntyre, Comparison of FDG-PET and Sestamibi-SPECT in Primary Hyperparathyroidism The Journal of Nuclear Medicine. ,vol. 37, pp. 1809- 1815 ,(1996)
Frederic Sebag, Johnathan G.H Hubbard, Sylvie Maweja, Claudia Misso, Laurent Tardivet, Jean-Francois Henry, Negative preoperative localization studies are highly predictive of multiglandular disease in sporadic primary hyperparathyroidism Surgery. ,vol. 134, pp. 1038- 1041 ,(2003) , 10.1016/J.SURG.2003.07.021